Hypoxia Increases Repopulating Ability of Myelodysplastic Syndrome Bone Marrow Cells

Culture of Bone Marrow from Patients of `Myelodysplastic Syndrome'

Cerebral malaria (CM) is the major life-threatening complication of Plasmodium falciparum infecti0n.A prominent clinical feature of human CM is increased lactate in both brain and cerebrospinal fluid, with sustained lactic acidosis being an important prognostic indicator. To investigate whether DCA, an activator of the pyruvate dehydrogenase complex, ameliorates lactic acidosis in the murine mo...

[Angiogenesis in bone marrow of myelodysplastic syndrome patients].

INTRODUCTION Angiogenesis is an element of physiological and some pathological processes. Recently various investigators have reported that angiogenesis is associated not only with solid tumors but also with hematological malignancies. OBJECTIVES The aim of this study was to assess angiogenesis in patients with myelodysplastic syndromes. PATIENTS AND METHODS We have measured bone marrow mic...

Allogeneic bone marrow transplantation for 93 patients with myelodysplastic syndrome.

We treated 93 patients with myelodysplastic syndrome using cyclophosphamide and either total body irradiation (n = 88) or busulfan (n = 5) followed by marrow transplantation. Sixty-five marrow donors were genotypically HLA-identical siblings and 28 were other family members or unrelated donors. Before transplantation all patients had either severe neutropenia or thrombocytopenia or had greater ...

Marrow repopulating ability of peripheral blood cells compared to thoracic duct cells.

Purification of Bone Marrow Clonal Cells from Patients with Myelodysplastic Syndrome via IGF-IR

Malignant clonal cells purification can greatly benefit basic and clinical studies in myelodysplastic syndrome (MDS). In this study, we investigated the potential of using type 1 insulin-like growth factor receptor (IGF-IR) as a marker for purification of malignant bone marrow clonal cells from patients with MDS. The average percentage of IGF-IR expression in CD34+ bone marrow cells among 15 no...